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The mechanisms that keep CpG islands free of methylation appear to involve binding of transcription factors and other transcriptional machinery or the act of transcription itself

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Because this mechanism works within the bodys existing regulatory framework: Natural somatostatin feedback inhibition remains intact GH release follows physiological pulsatile patterns The pituitary gland is stimulated rather than suppressed Risk of supraphysiological GH levels is minimized Clinical Evidence for Sermorelin Sermorelin has a well-documented clinical history

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