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5c) by linking a ZBP1-specific DNA aptamer to an E3 ligand via an N-acyl-N-alkyl sulfonamide linker

The literature search, article review, data extraction and results were completed by the PCRRT co-chairs, who submitted their results to the workgroup for discussion

Nyberg and colleagues

While this construct mimicked the first TCR signal upon CAR binding to its target antigen, they lacked the second signal necessary for efficient T-cell activation

but note that several studies have suggested that D2-MSNs may also contribute to reward-based motivation 6365 and that MSN subtype-specific actions may depend on different patterns of activation 66 ]