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Keywords The search was performed using the following keywords and their combinations: Nrf2, mesenchymal stem/stromal cells or MSCs, natural flavonoids, inflammatory diseases, oxidative stress, Keap1, Nrf2 inducers, MSCs-derived exosomes/conditioned medium, synergistic effects of flavonoids and MSCs, as well as specific disease terms such as rheumatoid arthritis, Alzheimers disease, etc

In CCVDs, CoQ10 could directly act on ECs to stimulate vasodilation and lower blood pressure

However, with the continuous use of targeted drugs, some patients exhibit resistance

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Many longevity practitioners evaluate biological age through: Body composition Blood biomarkers Inflammatory markers Metabolic health Epigenetic testing Functional performance Epitalon is being explored as a tool that may support a younger biological profile by targeting cellular aging mechanisms

XZ, YD, and QX reviewed and edited the manuscript