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As a side note, the observed modest response for the DMSO control was also incorporated into the model to take into account that a minor part of the pathway activation observed under the experimental conditions used is due to DMSO rather than DEM (see Supplement)

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Free Radic Biol Med 61:143150 DiNicolantonio J, McCarty M, O'Keefe J (2018) Antioxidant bilirubin works in multiple ways to reduce risk for obesity and its health complications