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Mol Neurobiol 53(1):648661 Yao W et al (2021) Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents

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The hallmark features of AD include the accumulation of amyloid-beta (A) and the formation of neurofibrillary tangles in the brain 1

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Any mice with obvious unexpected sickness (slow movement, messy hair, and a glassy eye) were excluded