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Recently, oleuropein, a polyphenol, was shown to have the senolytic potential in OA chondrocytes (Varela-Eirn et al., 2020)

388 Nrf2 inhibition Nrf2, frequently overexpressed in therapy-resistant cancers, represents a promising therapeutic target for ROS-mediated anticancer strategies, as demonstrated by Tamoxifen-resistant breast cancer cells that develop irradiation cross-resistance through Nrf2-driven antioxidant upregulation and a glycolytic shift, with Nrf2 inhibition restoring radiosensitivity in both cellular models and patient tumors (NCT00738777)

[27] A recent case series of 101 adults with asthma reported that macrolides (mostly azithromycin) and tetracyclines, either separately or in combination, appeared to be dramatically efficacious in a subgroup of "difficult-to-treat" (i.e., not necessarily refractory to high-dose inhaled corticosteroids but who did not take them) patients with severe asthma, many of whom also had the "overlap syndrome" (asthma and COPD)

Comet assay for DNA damage Cells in culture were untreated (DMSO, control) or treated with R001 at the indicated concentrations for 24 h, or in the case of H 2 O 2 (400 M), cells were treated for 1 h

Collectively, these findings indicate that Grx1 limits TDP-43 accumulation and thereby prevents its cytoplasmic aggregation

10.1016/j.jnutbio.2012.05.003 63 YantL