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In this view, we suggest researchers take these issues into account: 1

572 Hydroxylated chalcones can inhibit A aggregation and A-induced decrease in GPX4 and increases in lipid peroxidation and may be potential candidates for the treatment of AD

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Wang L, Xu W, Ma L et al (2017) Detoxification of benzo[ a ]pyrene primarily depends on cytochrome P450, while bioactivation involves additional oxidoreductases including 5-lipoxygenase, cyclooxygenase, and aldo-keto reductase in the liver

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