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(2025) established a obesity model fed by 1 week HFD in 6-week-old male C57BL/6J mice, and simultaneously gave them low dose (5 mg/kg), medium dose (50 mg/kg) and high dose (100 mg/kg) of cynaroside for 12 weeks

doi: 10.3390/toxins16060268

Gentiopicroside inhibits retinoblastoma cell proliferation, invasion, and tumorigenesis in nude mice by suppressing the pi3k/akt pathway

L., Shaklee, J

Recent studies have shown that the mTOR-related signaling system can either promote or inhibit ferroptosis in hepatocellular carcinoma cells (111, 112)