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These can include the development of xanthelasma, xanthomas, corneal xanthoma, Schnyder corneal dystrophy [96] [97] , corneal arcus, or lipid keratopathy [98] , as well as conditions like cholesterosis bulbi, asteroid hyalosis [98] [99] , atherosclerosis, central retinal artery occlusion (CRAO) [100] , and the buildup of lipid exudates within the retina, which is particularly associated with conditions such as DR and AMD, and coat's disease

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Whereas HIF1 appears to be expressed in nearly all cell types, RNA in situ hybridization on mouse embryos revealed that HIF2 expression is more restricted, and particularly abundant in blood vessels

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Supernatants (metabolic extracts) were stored at 80C until measurement