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doi: 10.1038/s41571-021-00509-w

Author contributions AEZ: Methodology, Writing review & editing, Data curation, Investigation, Resources

Risk factors for cardiovascular diseases, such as diet, smoking, hypercholesterolemia, and diabetes, are often associated with low-grade inflammation, which can induce trained immunity and subsequently affect bone marrow hematopoietic progenitor cells through epigenetic modifications, leading to chronic metabolic disorders and vascular inflammation (307)