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In Graves' disease, thyroid-stimulating immunoglobulins (TSI) bind to TSH receptors and chronically overstimulate the thyroid, leading to excess T3 and T4 production

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114 In response to various stimuli, macrophages can differentiate into two unique subsets, referred to as M1 (proinflammatory) or M2 (anti-inflammatory) macrophages

This study used a 0.25% dose of cuprizone, rather than the more commonly used 0.2% cuprizone dose 24 and included 2 weeks remyelination after the 3 week cuprizone administration 27