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Cucinotta D, Passeri M, Ventura S, and et al

The compound's development represents years of medicinal chemistry optimization, resulting in a 10-fold improvement in potency over parent compounds while maintaining excellent safety margins in preclinical studies

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Accordingly, enhancement of astrocytic glycogenolysis improved the outcome from ischemic stroke in vivo as well as increased the survival of neurons in astrocyte-neuron co-cultures exposed to OGD in vitro 57

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