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Disclosures: Vivienne Nguyen: Nothing to Disclose 2259 ABLATION OF NEURONAL SENESCENCE ATTENUATES THE COGNITIVE DEFICITS OBSERVED IN A MOUSE MODEL OF TYPE C HE Kathryn Rhodes 1 Juliet Venter 1 Matthew McMillin 2 Sharon DeMorrow 3 , 1 The University of Texas at Austin, 2 Baylor College of Medicine, Temple, 3 University of Texas at Austin Background: Hepatic encephalopathy resulting from chronic liver disease (Type C HE) is associated with neurological dysfunction and hyperammonemia