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Excess iron can damage the liver, heart and pancreas in these conditions [31] [35]
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Discussion Adverse environmental conditions including abiotic and biotic stresses induce the production of ROS [11] which damage cellular macromolecules such as proteins, lipids, nucleic acids and cell membranes
In an animal study, neonatal SOD1 G93A mice receiving injection of a single-stranded AAV9 vector encoding an artificial mRNA against human SOD1 in the cerebral lateral ventricles showed improvements in multiple parameters including survival, number of MNs, the extent of neuroinflammation, diameter of ventral root axons and pulmonary function [137]
