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All human studies were conducted in accordance with the principles of the Declaration of Helsinki

However, allosteric modulators, both positive and negative, may offer superior efficacy with less danger of downregulation

Cells were stripped with trypsin/versene, centrifuged in 1.5 mL tubes (900 g, 5 min) at 4C and redispersed in 30 mL PBS

doi: 10.2967/jnumed.119.229740 74 Seong-WooBJianboWDimitraKGXiaoxiaWAllisonSCLingGet al

The term of oncometabolites refers to intermediates of metabolism that abnormally accumulate in cancer cells upstream or downstream of metabolic defects, often through loss-of-function or gain-of function mutations, respectively, in genes encoding the corresponding enzymes (177)

The hemoglobin molecule is an assembly of four protein subunits, two alpha units and two beta units