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Blood-brain barrier dysfunction is a pathophysiological hallmark in the pathogenesis of multiple CNS diseases ( The Blood-Brain Barrier Establishment Angiogenesis and Barriergenesis Prior to BBB development, neuroectodermal neural progenitor cells secrete vascular endothelial growth factor (VEGF) to guide angioblasts from the perineural vascular plexus across the neuroectoderm to initiate angiogenesis (Potente et al., 2011

(2001) Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-Bdependent gene expression in keratinocytes are modulated by a French maritime pine bark extract

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IELs represent one of the largest, non-organized lymphocyte population (58) and constitute one of the most abundant T cell populations of barrier immune cells (5961)