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It was recently shown that pemetrexed may play a role in cisplatin resistance in lung cancer by increasing the expression of Orai3 calcium channels as well as the expression of certain ABC transporters like MDR1 and MRP-5 responsible for cisplatin efflux and therefore a reduction of the effect of cisplatin [16] As current therapies are based on the co-administration of pemetrexed and cisplatin, there may be interactions between pemetrexed and cisplatin, including a reduction in the therapeutic effects of cisplatin caused by pemetrexed

If your ovaries are overstimulated you should not have sex, or use barrier contraception for at least four days

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The Recommended Dietary Allowance (RDA) for vitamin B12 varies by age and condition: Adults: 2.4 mcg/day Pregnant women: 2.6 mcg/day Breastfeeding women: 2.8 mcg/day However, injection dosages are significantly higher and vary depending on the individuals condition

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Avoid repeated freezethaw cycles