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These criteria were later updated to allow for two titanium plates and one burr hole cover (18.5 mm diameter) and to permit smaller separations, assessed by an MR safety expert and a neuroradiologist, with scans performed in normal operating mode (scanner-reported 6-min local 10 g SAR limit of 10 W/kg)

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A recent meta-analysis showed a considerable inconsistency among the findings obtained by 74 original PD-focused metabolomics studies, potentially attributable to the different biospecimens analyzed, antiparkinsonian drugs-related effects, different disease stages, genetic background, ethnicity, diet, exercise level, and analytical platform employed 13

Increased stress susceptibility and impaired differentiation of astrocytes and neurons was found in co-cultures and in neural organoids generated from AxD patient-derived induced pluripotent stem cells with AxD-causing GFAP R239C mutation 334

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Moreover, its antioxidant properties help improve and maintain the integrity of the intestinal barrier, optimize nutrient absorption, and reduce inflammation-induced damage to the gut, supporting its use in promoting gut health (Mehmood et al., 2019