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the pi of one masking moiety may be in the range of 3 to 5, preferably 3.5 to 4.5, more preferably 3.9 to 4.5, while the pi of the other masking moiety is in the range of 5.0 to 7.0, preferably 5.5 to 6.0

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Genetically encoded rxYFP or roGFP2 probes have also become extremely valuable tools for noninvasive, ratiometric real-time redox measurements in various compartments, cells, and organisms 64,65,66,67,68,69,70,71

European Journal of Clinical Pharmacology , 43(6), 667-669