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Description

Upon entering systemic circulation and reaching bone tissue, 5-HT attaches to the 5-HTR1B receptor on osteoblasts, which inhibits cAMP response element-binding protein (CREB) activity and cyclin expression, thereby suppressing osteoblast proliferation and differentiation and ultimately hindering bone formation (256)

J Am Nutr Assoc

doi: 10.1159/000439131 43 BoydAEDeFordLLMaresJELearyCCGarrisJLDagohoyCGet al

Free Radic Biol Med 34:145169 Imai H, Hirao F, Sakamoto T, Sekine K, Mizukura Y, Saito M, Kitamoto T, Hayasaka M, Hanaoka K, Nakagawa Y (2003) Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene