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The SPIONs and the quantum dots used in the formulation have a size of ~20 nm and ~8 nm, respectively, and the hydrodynamic diameter of the final liposome was determined to be ~100 nm

Physiol Rev 98(4):2381-2430

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The finding underscores the therapeutic potential of metformin in modulating epigenetic changes and offers a novel strategy for ESCC treatment, especially in smoking patients [150]