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doi:10.1007/s00253-001-0902-7

VEGF links hippocampal activity with neurogenesis, learning and memory

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These data from multiple experimental paradigms and various assays demonstrated that the efficacy of cGP on endothelial cells was the result of interacting with IGF-1, which normalises homeostasis by inhibiting or stimulating or maintaining IGF-1 activity, depending on whether the IGF-1 induced angiogenesis was excessive, insufficient or within a moderate, perhaps physiological range, respectively

In laboratory studies, survodutide shows an EC50 of approximately 8 nM for the glucagon receptor and 1 nM for the GLP-1 receptor