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Also described herein are agents that can detect the copy number, amount, and/or activity of at least one biomarker (e.g., at least one target listed in table 1 and/or table 2), such that the agents can be used to diagnose, prognose, and screen for effects mediated by at least one biomarker (e.g., at least one target listed in table 1 and/or table 2)

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