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In general, GPX4 homeostasis is affected by both selenocysteine biosynthesis/uptake ( 2.2 Lipid peroxidation Lipid peroxidation is a biomarker of ferroptosis ( 2.2.1 ACSL 4/LPCAT 3 A synthetase long-chain family (ACSL) is a major enzyme involved in lipid metabolism in vivo , notably facilitating the production of fatty acids with carbon chains ranging from 12 to 20 ( Meanwhile, ACSL4 is regulated by multiple factors, such as integrin 64-mediated inhibition of ACSL 4 expression by Src and signal transducer and activator of transcription 3 (STAT3) or activation of the androgen receptor ( LPCAT3 is a member of the LPLAT family of lysophospholipid acyltransferases

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Data were acquired in data-independent acquisition PASEF mode with the following settings: m / z range from 100 m / z to 1,700 m / z , ion mobility range from 1/K 0 = 1.300.85 V s cm 2 using equal ion accumulation and ramp times in the dual TIMS analyser of 100 ms each

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Proc West Thorac Surg Soc 66:22, 2001

Previous studies in our laboratory have shown that the mechanisms of aspirin and H