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Melatonin supplementation inhibits amyloidogenesis and attenuates neurodegenerative disorders The conundrum of resolving contradictory results from in vivo and in vitro experiments on melatonin and amyloid disaggregation The results obtained from in vivo studies delineated a distinct dose- and time-dependent relationship between melatonin supplementation and the prevention of amyloid deposition-induced neurodegenerative symptoms in healthy and diseased animals tested

(B) LRs from dHL60 cells were extracted with MNE buffer containing 1% triton X-100 and applied to discontinuous sucrose gradients, as described in Methods

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