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Treatment with the RIPK1 inhibitor Nec-1 concurrently blocks both necroptosis and ferroptosis, and its protective effect is significantly superior to that of ferrostatin-1 or z-VAD alone (145)

BMC Pharmacology and Toxicology, 26 (1), Article 120

M.Baer-DubowskaW

doi: 10.3390/cimb45120588

doi: 10.1016/j.fbio.2023.102901 211

Based on this, it has been confirmed that prescribing lenalidomide with EGFRvIII-CAR-T cells elevated the F-actin polymerization and the CAR-T cell infiltration and cytotoxicity in the tumor site of the glioblastoma murine model, leading to prolonged survival of treated mice [114]