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Nat Cell Biol 16:5565 Janko C, Filipovi M, Munoz LE, Schorn C, Schett G, Ivanovi-Burmazovi I, Herrmann M (2014) Redox modulation of HMGB1-related signaling

In a study of West Nile virus (WNV) infection, it was found that cerebellar granule cell neurons (GCNs) had higher levels of type I interferon-induced gene expression compared to cortical and Purkinje neurons, thus exhibiting greater resistance to viral infections [48]

The results become murky, inconsistent, and ultimately, unreliable

These inflammatory mediators and toxic compounds cross the bloodbrain barrier, contributing to neuroinflammation, microglial activation, and oxidative stress within the central nervous system