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Martnez de Toda et al., 142 , which is generated by the cleavage of amyloid precursor protein (APP), by enzymes such as -secretase 1 (BACE1) and increases oxidative stress

The endocrine factor FGF15/19 (mouse FGF15, human FGF19) is highly expressed in ileal enterocytes and released postprandially to critically suppress BA synthesis in the liver

Several natural compounds reduce A toxicity by inhibiting its aggregation, promoting its clearance via autophagy, and limiting synaptic dysfunction (Zeng et al., 2019)

Patients with thrombocytopenia due to an underlying disease or condition will also be managed by the specialists that treat these underlying conditions, including infectious disease specialists, rheumatologists, oncologists, and others