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For example, the polyol pathway, which is responsible for converting glucose to fructose, increases under hyperglycemia in the insulin-insensitive tissues

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Mitochondrial biology and dysfunction: core mechanisms Physiological functions of mitochondria Mitochondria, as double-membraned organelles characterized by distinct structural and functional domains including the outer mitochondrial membrane (OMM), inner mitochondrial membrane (IMM), intermembrane space (IMS), and mitochondrial matrix, play a multifaceted role in cellular physiology

Experimental observations in Escherichia coli

The amount of intracellular Fe2+, a ferroptosis-related marker, was significantly increased under the low-concentration treatment condition, indicating that it tends to increase before actual cell death occurs

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