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June 26, 2026 Key Takeaways The First-Pass Barrier: Traditional

Some researchers report stable results up to 45 or 60 days, but 28 days is the window within which potency is most reliably maintained

Poor blood supply slows the rate at which fibroblasts and other wound-healing cells can reach the area of injury and, ultimately, restricts the overall level of repair that can take place

Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)