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For all PEA doses there is an increase in negative volume of activation over vehicle

The microbial metabolite itaconate reduces Th17 differentiation and promotes Treg generation by inhibiting both glycolysis and OXPHOS (173)

Prabhakaran S, Gonzalez N, Zachrison K, Adeoye O, Alexandrov A, Ansari S, Chapman S, Czap A, Dumitrascu O, Ishida K, Jadhav A, Johnson B, Johnston K, Khatri P , Kimberly W, Lee V, Leslie-Mazwi T, Mac Grory B, Madsen T, Menon B, Mistry E, Park S, Parker S, Prez de la Ossa N, Reeves M, Saiz T, Scott P, Schwartzberg D, Sheth S, Sporns P, Times S, Tjoumakaris S, Wolfe S, Yaghi S, Leira E, Broderick J, Arauz A, Ardelt A, Bahouth M, Caulfield A, Derdeyn C, Dylla L, Frankel M, Fullerton H, Guerrero W, Jauch E, Kicielinski K, Labram Y, Lyden P, Marsh E, Meurer W, Mocco J, Pandey A, Rabinstein A, Rapp K, Richards C, Rocha M, Royan R, Samaniego E, Sangha N, Schirmer C, Simpkins A, Streib C, Tirschwell D, Zink E

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doi:10.1371/journal.pone.0041298

et al., 2020