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FEBS Lett 589(1):165171

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

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Various studies have demonstrated that patients suffering from diabetes, severe obesity, hypertension and cardiovascular disease are more prone to experiencing unfavorable outcomes following infection with COVID-19 ( 3 Pathogenesis of septic ARDS Sepsis is the most common pathogenic factor of ARDS, which can cause ARDS in less than a week, and the prognosis of those patients is poor ( Figure 1 )

This system balances redox status by transferring electrons from NADPH to Trx-R, which then reduces disulfide bonds in Trx, allowing it to restore functional thiol groups on various target proteins 60,61