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The activation of protein kinase C isoforms and (PKC/), along with the upregulation of NADPH oxidase, further enhances ROS production ( Due to its hydrophobic nature, 4-HNE readily integrates into the mitochondrial phospholipid bilayer, disrupting lipid organization and increasing membrane permeability (Santin et al., 2020)

Oxidative Medicine and Cellular Longevity, 2016 , 3286365

Chronic inflammation has been associated with the development of malignancy in several other organs such as the oesophagus, stomach, colon, liver and urinary bladder

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