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Losing weight is not the only way to fight obesity

Neurons are particularly vulnerable to oxidative damage in the presence of OS and NS because of several factors involving, among others, the presence of large amounts of polyunsaturated fatty acids in their lipid bilayers, the high dependence on paramagnetic oxygen for neuronal survival, and the high metabolic rate of neurons and glia with attendant free radical leak from mitochondria (8)

In a 12-week study, 33 non-diabetic adults were stratified around the median plasma apoB into a high-apoB (123 mg/dL) group (n = 17) and a healthy-apoB (85 mg/dL) group (n = 16)

Neuroscience 129 (4), 10211029

In addition to the above epidemiological findings, many pre-clinical laboratory studies have focused on the impact of IGF-1 in cancer cell proliferation, migration, tumor growth and metastasis using in vitro and in vivo models to identify the signaling pathways involved in these processes