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GGC also upregulated the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-, IL-6, and IL-1) and attenuated the changes in metalloproteinase activity in oligomeric A 40 -treated astrocytes

Reduced ROS levels also increase the bioavailability of nitric oxide (NO), which can significantly reduce blood pressure

Some sensitive patients may benefit from microdosing (below 0.25 mg) or customized compounded formulations to improve tolerance

The application of Pt nanozymes against organ-specific toxicity requires precise targeting to the injured organ (e.g., liver, kidney) to avoid unintended redistribution

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Cost considerations may represent significant barriers to access, as these peptides are typically not covered by health insurance and may represent substantial out-of-pocket expenses for patients