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It can also regulate SIRT1-mediated HMGB1 deacetylation to protect against HFD or PA induced hepatic steatosis and inflammation [74]

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Iron and copper metabolism are interconnected, with key regulatory nodes, such as mitochondrial function, ROS levels, inflammatory signaling and the balance of iron/copper/cystine, serving as pivotal points in the crosstalk between these death pathways (210)

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7 Molecular, biochemical, and metabolic plant responses toward HMs 7.1 Negative impact of metals on plants Exposure to HMs causes several reactions in plants, including physiological, biochemical, and agricultural production responses (Singh et al., 2020)