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Collectively, polymeric nanocarriers (PLGA, chitosan, gelatin) provide versatile platforms to enhance curcumins therapeutic index

Apart from the iron serving as co-factors and the iron stored in ferritin, the remaining divalent iron in the cytoplasm (a concentration of approximately 0.55 m) is called the free iron pool (Espsito et al., 2002

When the nanoparticles were irradiated by X-rays, the CaWO4 core emitted ultraviolet and blue light, which was absorbed by bilirubin to produce a photodynamic effect, generating ROS to enhance cancer cell death

INO binds A2A receptors with lower affinity than ADO and preferentially activates ERK1/2 over cAMP signaling ( Targeting the CD38/NAD + axis remains an attractive immunotherapeutic strategy in MM, but the broad expression of CD38 raises concerns about off-target toxicity ( Supplementary Table 1 ), ADA-based degradation ( + surrogates ( Overall, our findings indicate that anti-CD38 therapies engage a dynamic, compartmentalized adenosinergic network in MM, with metabolic adaptations that may influence therapeutic responses

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