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Epigenetic modifications have been reported to induce a series of changes in gene expression and protein levels that result in mitochondrial abnormalities and neuronal apoptosis and lead to PD (Zhang et al., 2021), long non-coding RNAs ( Mitochondrial Quality Control in Parkinsons Disease Quality control mechanisms are essential to maintaining a healthy mitochondrial network and cell homeostasis, especially to dopaminergic neurons

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Reaction 3: 6-Phosphogluconate + NADP Ribulose-5-Phosphate + CO + NADPH + H The second reaction involves the oxidation of 6-phosphogluconate, which results in the production of NADPH, carbon dioxide (CO), and ribulose-5-phosphate