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The frequency of these events varies by ethnicity, with Asians having the highest frequency of loss-of-function mutations (50%), and Whites the least (9%) (Nakajima et al., 2006

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Shen et al., 2018

Conversely, oxysterols of exogenous origin arise from the natural oxidative processes occurring in dietary cholesterol or during the preparation of cholesterol-rich foods

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In the same study, wild type mice injected with ibrutinib also showed reduced micro- and astroglial activation