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Importantly, animal studies using non-human primates and rodents have also revealed demyelination with age, providing a reliable model for researchers to try and understand the cellular mechanisms at play

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Vascular dysregulation, as described above, not only damages RGCs but also activates glial cells that support the RGCs, such as astrocytes.[2, 52] Activated astrocytes change the micro-environment by releasing several compounds, such as matrix metalloproteinases (MMPs)

When APP is cleaved by alpha-secretase, it prevents Amyloid Beta production and reduces memory loss risk

Data availability The datasets are available from the corresponding authors upon reasonable request