immediate cellular glutathion precursor Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy Glutathione-dependent redox balance characterizes the

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Specifically, GA significantly increased the expression of PGC1 target genes such as mitochondrial transcription factor A, nuclear respiratory factor-1, and nuclear respiratory factor-2, thereby upregulating fatty acid -oxidation enzymes like carnitine palmitoyltransferase-I, and promoting fatty acid oxidative metabolism in mitochondria (Doan et al., 2015)