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Chem Rev 114(1):815862

T-cell receptors activate calcineurin by increasing intracellular calcium through calmodulin to elicit the T-cell response

As a co-therapy like in case of combined collagen crosslinking (CXL) and intrastromal corneal ring segment (ICRS) implantation to treat keratoconic eyes, no adverse effect from the riboflavin injections were reported (32)