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May support improved tissue function by reducing the senescence-associated secretory phenotype (SASP)

[76] pre-treated ADMSCs with SAG, as a specific signal agonist of the Shh signalling pathway, and found that the combination of SAG and TGF-3 significantly increased the gene and protein expression of NP-specific markers at the molecular level as well as the macromolecular level, and significantly changed the IVD height, water content, ECM content, and structure (Table 5)

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