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patients with CKD, those on nephrotoxic medicines, or those who are pregnant should seek specific clinical advice before use

There are also gel formulations of B12, available as a prescription medication, that is applied to the inside of the nose

Bioavailability also favors injection

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For example, those with more severe deficiencies or certain health issues might need different doses

The risk of relapse should be weighed against the risks of long-term thiopurine therapy