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In dermal fibroblasts cultured from aged donors, GHK-Cu treatment (2 M) increases TIMP-1 mRNA expression by approximately 25%, contributing to reduced net collagenolytic activity and preservation of existing matrix structures

Liposomal delivery systems have been shown to promote the retention of collagen within artificial membranes and elevate the expression of structural skin proteins such as collagen, keratin, and involucrin, contributing to improved skin elasticity and reduced signs of ageing [212]

The application of atorvastatin reduced the Firmicutes / Bacteroidetes ratio to a level close to that of normal mice (22), among which the abundance of butyrate-producing Firmicutes (such as the Faecalibacterium ) had been increased by statins (119)

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