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This mitochondrial GSH depletion is accompanied by evidence of mitochondrial oxidative stress, including increased levels of 8-OHdG, and significant loss of aconitase activity, a mitochondrial enzyme particularly sensitive to inactivation by superoxide radical (Velsor et al., 2006)

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Interestingly, around 70%80% of psychotropic (including antidepressant) medications are prescribed in primary care practices (280)