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To examine whether BNIP3 is in close proximity to BAX and BAK1, we profiled wild-type, Bax knockout ( Bax / ), and Bak knockout ( Bak / ) mouse embryonic fibroblasts (MEFs) utilising in situ proximity ligation assay under baseline conditions (PLA, Supplementary Fig

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In fact, it is well-documented that inhibition of key components of mTOR and its counterpart in invertebrates TOR pathways, results in an extension of life span in part by the influence of mTOR on the called hallmarks of aging, an interesting an extensive review about this subject is broadly reviewed in Papadopoli publication (173)