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Synthetic liquid medium supplemented with 13 C-labeled methylesterified PGA consisted of 0.67% yeast nitrogen base without amino acids and 0.5% (w/v) 13 C-labeled PGA (1.8% methylester content, 5% 13 C-labeled methylester group)

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Common (5-15% of users): Mild injection site reactions, minor digestive changes Uncommon (1-5%): Sleep changes, temporary fatigue, mild headache Rare (under 1%): Dizziness, flushing, mood changes Very Rare: Serious adverse effects rarely reported in community use Theoretical Concerns BPC-157s ability to stimulate angiogenesis (blood vessel formation) raises theoretical questions about its use in individuals with active cancer or high cancer risk

Formalin-induced nociceptive behavioral test (formalin test) All experiments were prepared as in the previous formalin model study described by Dubuisson and Dennis [9]

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