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This interaction promotes fibroblast activation and proliferation [105] and upregulates the expression of pro-fibrotic markers -SMA, desmin, fibronectin, and collagen I [6, 103] (Fig

Eur Heart J 2011

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These include the quadriceps group, especially the vastus medialis and vastus lateralis, as well as the hamstrings, gastrocnemius, popliteus, and even the hip muscles such as the gluteus medius and hip adductors

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Future studies should aim to dissect the individual roles of aurora kinase inhibition versus PI3K/Akt activation in mediating neuroprotection, employing selective inhibitors or genetic approaches