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In contrast to saline-injected WT mice, saline-injected Gpx1 KO mice showed low GSH/GSSG ratio, increased hydrogen peroxide and high MDA level in the liver and spleen (Figure 6)

Moreover, markers of senescence, such as SA--gal and SASP, have been detected in patients treated with IR [91]

These conformational changes also impair the rearrangement of the PIF motif, ERY motif, and NPxxY motif (Supplementary Fig

The triple mechanism works through complementary pathways

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have been extensively reported to be correlated with this change [5,6,7]